"World DNA Day": Genomics a key tool in the battle against Covid-19

  • DNA contains all the genetic information, the design instructions of each and every one of us and the rest of living beings, from the simplest bacteria to the most complex organism.
  • Genomics is one of the key tools in the fight against Covid-19. It allows a new and more efficient approach in the development of medicines and vaccines and to know if there are genetic variants related to the type of response of each person to this virus.

  • In 2003, the Human Genome Sequencing was completed, a project started in 1990 in which more than 3,000 million dollars were invested and in which universities and research centers in the United States, Canada, New Zealand, and the United Kingdom participated. Kingdom and Spain.

  • Technological advances and the exponential reduction in the cost of complete genome sequencing have created a new paradigm both in the field of clinical diagnosis and in preventive and personalized medicine and in health care. [19659003] Today, April 25, is celebrated World DNA Day (deoxyribonucleic acid) the molecule that contains the information of life. In 1953 James Watson and Francis Crick discovered the structure of DNA, recognized with the Nobel Prize in Medicine in 1962. A discovery considered one of the great advances of the 20th century.

    DNA contains all the genetic information, the design instructions of each and every one of us and of the rest of living beings, from the simplest bacteria to the most complex organism. There are tens of thousands of genes in DNA. They are in charge of manufacturing the proteins necessary for the development of the different vital functions.

    Genomics and Covid-19

    Genomics is one of the key tools in the fight against Covid-19 . Virus sequencing enables an effective approach to drug and vaccine development. Likewise, the sequencing of the genome of people who have suffered from the disease will allow us to know if there are genetic variants related to the type of response of each person to this virus.

    Since the beginning of the pandemic, very different reactions to the virus have been seen . Some people hardly notice the contagion, others end up in the ICU and thousands die. Each person's response to the virus, regardless of age, sex or health, is also related to genetic variability, and knowing which genes can make us more vulnerable is vital in prognosis and treatment.

    international project The Covid-19 Host Genetics Initiative is promoting studies in patients with coronavirus to find out if genes make a patient more vulnerable. To do this, genetic analyzes will be carried out on 8,000 patients in the coming months to analyze certain markers – what is known as a ‘whole genome association study’ or GWAS. It will be completed with the completion of 300 complete genomes, to analyze in detail the variants found.

    Many small differences in the genome could explain why some people who have contact with the virus develop a serious disease, while the majority have symptoms similar to those of a flu or not even that. The study will make it possible to know if there is any type of predisposition that is not clinically evident, such as inflammatory processes that can be anticipated with certain genetic markers or find certain associations in gene variants that can aggravate the development of the disease.

    Furthermore, this information will be key to treatments. Both in the reuse of certain drugs that are already on the market and in the development of new ones. In addition, it will allow you to personalize each patient's medication and identify incompatibilities with certain medications.

    Human Genome Project and genomics

    In 2003 the Sequencing of the Human Genome was completed, a project started in 1990 in which more than 3,000 million dollars were invested and in which universities and research centers from the United States, Canada, New Zealand, the United Kingdom and Spain participated. Genomics was born from him, an interdisciplinary field of science within molecular biology that focuses on the structure, function, evolution and mapping of genomes.

    Advances in genomics have triggered a revolution in research that helps understand even the most complex biological systems like the brain. In contrast to genetics, which refers to the study of individual genes and their roles in heredity, genomics uses high-throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. [19659011] Technological advances and the exponential reduction in the cost of complete genome sequencing have created a new paradigm both in the field of clinical diagnosis and in preventive and personalized medicine and in prevention and health care.

    Sequencing generalized Genome in the population allows to personalize health care and, in certain cases, anticipate the appearance of a series of diseases towards which there is a genetic predisposition.

    A recent study, carried out by the prestigious J. Craig Venter Institute, in which the Genome of 1,190 people was analyzed, showed that 206 of these people -17% of the total- present They had at least one pathogenic or probably pathogenic variant that increased their predisposition to present some pathology. Key information that allows you to personalize your medical care and act before the appearance of the first symptoms.

    This study -comments doctor Luis Izquierdo medical director of Veritas Intercontinental demonstrates the clinical utility of Genome sequencing to prevent and detect subclinical diseases in healthy populations. The investigations that are being carried out to determine which people are more susceptible to serious infection or severe complications by covid-19, if they are successful, will be another very important tool that genomic sequencing provides for the management of this disease in a personalized .

    The Genome has shown that it has a crucial role, since the information contained in genes contains the code of life and is different for each person. The ability to know the strengths and weaknesses of each person is a key tool for adapting medical care, applying lifestyle modifications and prevention strategies that prevent or mitigate the development of such frequent disorders as cardiovascular diseases or metabolic disorders. The exponential reduction in the cost of Genome sequencing and its extension to "healthy" people is accelerating the application of precision medicine and providing new information to the study of genes and their pathogenic variants.

    About Veritas Intercontinental

    Veritas Intercontinental, The Genome Company which operates in Europe, Latin America, Japan and the United Arab Emirates. Its mission is to promote the sequencing of the whole genome and offer people information that empowers them to maximize the quality and duration of their lives and that of their families, changing the way the world conceives genetics.

    Veritas was the first company to offer whole genome sequencing and interpretation to consumers and their physicians and leads the field of genetics, pushing the boundaries of science and technology and lowering the cost of the genome.

    Founded in 2014 by leaders in genomics from Harvard Medical School operates worldwide from its offices in the United States, Europe, and China. The company has been recognized MIT Technology Review as one of the 50 Smartest Companies in 2016 and 2017, by Fast Company as one of the companies of world's most innovative health in 2018, and by CNBC as one of the companies Disruptor 50 in 2018 and 2019.

Leave a Reply

Your email address will not be published. Required fields are marked *